Medical Paper Papers
1: J Laryngol Otol. 2002 Apr;116(4):261-3.
Effect of anti-fungal nasal lavage with amphotericin B on nasal polyposis.
Ricchetti A, Landis BN, Maffioli A, Giger R, Zeng C, Lacroix JS.
Rhinology Unit, Department of Otorhinolaryngology - head and Neck Surgery, Geneva
University Hospital, Switzerland.
Recent studies have suggested that allergic fungal rhino-sinusitis could be involved
in the development of nasal polyposis. The aim of this study was to evaluate the
response of anti-fungal nasal lavages. Patients performed nasal lavage with 20 ml
of a one per one thousand amphotericin B suspension in each nostril, twice a day,
for four weeks. In addition, all patients continued their saline nasal lavage and
their conventional topical corticosteroid spray. This study included 74 patients,
with a mean age of 46 years (range from 19 to 73). Before anti-fungal treatment,
the distribution of nasal polyposis, according to Malm, was: 13 patients in stage
I (17.5 per cent), 48 patients in stage II (65 per cent) and 13 patients in stage
III (17.5 per cent). After anti-fungal nasal lavages, the total disappearance of
nasal polyposis was observed in 29 patients (39 per cent). Eight patients were stage
I, 21 stage II, and none stage III. In patients who have had previous endoscopic
polypectomy and functional endoscopic sinus surgery, total disappearance of nasal
polyposis was seen in 24 patients (47 per cent). Hyper-reactivity to fungal organisms
could be one of the mechanisms underlying the development of nasal polyposis. A
direct effect of amphotericin B suspension on the integrity of the cell membrane
of the polyps` epithelium could not be excluded.
PMID: 11945184 [PubMed - indexed for MEDLINE]
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